Tuesday, December 26, 2017
Friday, December 15, 2017
Melatonin as a Pleiotropic Molecule with Therapeutic Potential for Type 2 Diabetes and Cancer
Background: The incidence of both type 2 diabetes (T2DM) and cancer is increasing worldwide, making these diseases a global health problem along with increasing healthcare expenditures. The current therapeutic approaches for treating these multifactorial diseases are far from satisfactory. As increasing evidence shows beneficial effects of melatonin (MLT) on typical pathological changes occurring during the development of T2DM and cancer, the present review focuses on molecular aspects of antidiabetic and anticancer activities of MLT and, moreover, discusses several future directions of research regarding MLT application as potential therapeutic agent.
For More Details Please Visit: Melatonin as a Pleiotropic Molecule
Wednesday, December 13, 2017
Sunday, December 3, 2017
Tuesday, November 28, 2017
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Monday, September 18, 2017
Monday, September 4, 2017
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Monday, July 31, 2017
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Tuesday, May 9, 2017
Thursday, April 27, 2017
Monday, April 17, 2017
Thursday, April 13, 2017
Regulation of Platelet Function by Acetylation/Deacetylation Mechanisms
Regulation of Platelet Function by Acetylation/Deacetylation Mechanisms
[ Vol. 23 , Issue. 35 ]
Author(s):
Ana Latorre and Antonio Moscardó Pages 3966 - 3974 ( 9 )
Abstract:
Reversible acetylation of histones is a well-known mechanism of epigenetic regulation of gene expression. More recently, studies have demonstrated that acetylation/deacetylation in several proteins regulate multiple aspects of cellular activity, especially those associated with energetic metabolism. Platelets are key participants in haemostasis and cardiovascular diseases. Although metabolic changes such as diabetes or lipidemia are well recognized risk factors for cardiovascular diseases, there is very little information about the relationship between metabolism and platelet reactivity. Recent studies have reported that different aspects of platelet function such as adhesion, aggregation, or granule release could also be regulated by acetylation of proteins. These cycles of acetylation/deacetylation are regulated by the contrasting action of acetyltransferases and deacetylases, which have been described by the presence of p300 and HDAC6, and sirtuins, respectively, in platelets. Remarkably, deacetylases, especially sirtuins, have been the subjects of intensive pharmaceutical research due to their implication in several physiological and pathological processes in organisms. The discovery of acetylation mechanisms in platelets opens new possibilities for the treatment and prevention of cardiovascular diseases through the regulation of acetylases/deacetylases in platelets. Therefore, the aim of this review is to present some recent reports concerning the role of acetylation of proteins in the control of platelet function, and the new possibilities of regulation of platelet function that this represent.
Keywords:
Acetylation, platelets, cardiovascular disease, aspirin, cancer, sirtuins.
Affiliation:
IIS La Fe, Hospital Universitario y Politécnico La Fe, Avd Fernando Abril Martorell, P.O. Box: 46026, Valencia, Spain.
Wednesday, April 12, 2017
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